Supply chain attacks pose a significant cybersecurity threat, targeting third-party vendors to infiltrate organizations' systems, as seen in high-profile incidents like SolarWinds and Kaseya. To mitigate risks, organizations should conduct thorough vendor assessments, implement strong access controls, monitor vendor activity closely, use multi-factor authentication, and maintain robust incident response plans. Collaboration and sharing threat intelligence are also crucial in fortifying defenses against evolving supply chain vulnerabilities.